Bioanalytical Chemistry/DMPK (China)

Overview

The professional staff in the DMPK (Drug Metabolism & Pharmacokinetics) Department at Bridge in Beijing can meet your needs in every phase of the drug discovery and development process. We offer a wide variety of GLP-compliant study and discovery services to support Bioanalytical Chemistry (for small molecules) and DMPK research.

 

These services include:

• Analytical method development and validation

• Bioanalytical method development and validation

• Homogeneity and stability in dose formulations

• In Vitro ADME: metabolic stability, metabolic profiling, inhibition, induction, metabolite ID, enzyme ID, permeability, transporter plasma protein binding RBC ratio

• In Vivo ADME: metabolic profiling, inhibition, induction, metabolite ID, BBB ratio

• Metabolic disposition with ¹⁴C- or ³H-labeled compounds

• Pharmacokinetics (PK) in animals (mice, rats, NHPs, dogs)

• Toxicokinetics (TK) in animals (mice, rats, NHPs, dogs)

Laboratory Resources

The state-of-the-art Beijing facility incorporates advanced technology and major instrumentation to speed up drug research and development:

• Animal facility (AAALAC accredited) for in-life and ADME studies, in both small and large animal species (GLP and non-GLP)

• Provantis™ software for clinical observations

• Dispense software for test article tracking and formulation

• Agilent 1200 HPLC system with DAD and fluorescent and electrochemical detectors

• Agilent 6410 LC-MS/MS system

• API 3200 Q-Trap LC-MS/MS system (Agilent 1200, DAD and HTC leap autosampler)

• API 4000 Q-Trap LC-MS/MS system (Agilent 1200, DAD and HTC leap autosampler)

• PE 1470 Wizard Gamma Counter

• PE 307 Sample Oxidizer

• PE Radiomatic 610TR Flow Scintillation Analyzer

• PE Tri-Carb 2900TR Liquid Scintillation Analyzer

• WinNonlin® software for PK/TK modeling