Toxicology (China)

Overview

The Bridge Laboratories facility in Beijing includes one of the largest vivariums in China, built from the ground up to be US GLP-compliant. This state-of-the-art facility — located in the largest life sciences park in China — is also CMST (Chinese Ministry for Science and Technology) approved and AAALAC accredited. The vivarium houses a variety of animal species, including mice, rats, rabbits, canines and primates.

 

All GLP studies are audited by an independent Quality Assurance Unit (QAU), comply with US FDA Good Laboratory Practices (GLP; 21 CFR Part 58), and are managed with US-level animal welfare oversight. In addition, the laboratory has a fully functioning Institutional Animal Care and Use Committee (IACUC).

Preclinical Toxicology Services

Bridge toxicology professionals in the US have in-depth expertise in a number of critical areas:

 

Types of Studies Dose-range finding Pharmacokinetics/toxicokinetics (PK/TK) Single dose (acute toxicity) Repeat dose (subacute, subchronic, chronic) With in-house pathology capabilities (clinical pathology, histopathology) Species Mouse Rats Rabbit Canine Non-human primates

Compunds Biologics Natural products Small molecules Routes of Administration Oral (gavage, water, capsule) Intravenous (bolus injection and infusion) Intramuscular Subcutaneous Intraperitoneal Dermal/Intradermal Ocular (topical)